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This papule leads to an ulcer with raised edges, regular contours, and coarse granulation, either covered or not covered with seropurulent exudate. In CL, an elevated erythematous papule develops at the bite site weeks or even years later. The infecting species and the interaction with the host will determine how the infection presents. There are four major clinical forms of leishmaniasis: cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), diffuse cutaneous leishmaniasis (DCL), and visceral leishmaniasis

Leishmaniasis is endemic to the Middle East, North Africa, parts of Europe, and Central and South America The infection is transmitted by sandflies, and a wide variety of domestic and wild vertebrates serve as parasitic reservoirs however, humans are accidental hosts in the Americas. Leishmaniasis is a chronic infection caused by several protozoan species of the genus Leishmania.

Authors' contribution: LLS: conception and planning of the study elaboration and writing of the manuscript effective participation in research orientation critical review of the literature VMM: elaboration and writing of the manuscript obtaining, analysis and interpretation of data effective participation in research orientation critical review of the literature IRMMA: analysis and interpretation of data effective participation in research orientation intellectual participation in propaedeutic and/or therapeutic management of case studies critical review of the literature GAG: approval of the final version of the manuscript conception and planning of the study elaboration and writing of the manuscript obtaining, analysis and interpretation of data effective participation in research orientation critical review of the literature LPT: conception and planning of the study elaboration and writing of the manuscript obtaining, analysis and interpretation of data effective participation in research orientation RGC: approval of the final version of the manuscript conception and planning of the study elaboration and writing of the manuscript intellectual participation in propaedeutic and/or therapeutic management of case studies critical review of the literature, critical review of the manuscript.

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